The Solid Tumor team at Knight Diagnostic Laboratories performs diagnostic and clinically actionable tests developed at Oregon Health and Science University. The department includes a variety of molecular platforms which allow testing to be developed using the most appropriate technology for the application. Testing includes high resolution melting curve (HRM) analyses which are fast and cost-effective for screening oncogene mutations, pyrosequencing, and Sanger next gen sequencing using LNA-clamps for detecting mutations with high sensitivity (1% mutant allele).
Our GeneTrailsTM solid tumor panel (Ion Torrent® platform delivers information on 37 genes commonly involved in solid tumors. The panel has a sensitivity of ~5-15% mutant allele, depending upon the gene. More custom panels including a lymphoma panel and upgrades to the Solid Tumor Panel are in development and will be clinically available in the near future.
Targeted panels are available for the following tumor types: